Our mission at Interconnected & Integrated Bioelectronics Lab (I²BL) is to realize personalized medicine for everyone! We create new classes of implantable, wearable, and mobile bioelectronics that acquire highly specific information about our body’s dynamic chemistry (e.g., by measuring circulating biomarker molecules) and provide appropriate feedback (e.g., precision dosing). To create these bioelectronics: 1) we engineer materials with specialized properties (e.g., soft, strain-insensitive, stimuli-responsive); 2) we develop micro/nanoscale actuation and sensing methodologies to control, isolate, and sense a spectrum of biomarkers (e.g., electrochemical sensors to measure metabolites, electrolytes, nutrients, hormones, and pharmaceuticals); and 3) we fabricate microfluidic, microneedle, flexible, and/or stretchable devices to interface with biological entities such as biofluid and tissue. In our approach, we emphasize solutions that are simple, low-cost, and scalable, all while providing new functionalities to bypass performance boundaries of conventional biomedical tools. By integrating these solutions into autonomous bioanalytical platforms and collaborating closely with prominent clinical experts and medical centers, we translate our technologies in clinical applications.